Multiple system atrophy (MSA) is a rare neurodegenerative disorder that shares several characteristics with Parkinson’s disease. The two conditions have similar symptoms, and they are diagnosed in similar ways. However, MSA — first known as Shy-Drager syndrome — is its own disease.

MSA is characterized by symptoms that affect both the autonomic nervous system (the part of the nervous system that controls involuntary actions such as digestion) and the movement system. The estimated prevalence of MSA is 4.4 cases per 100,000, and the condition typically affects people over 40.

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